Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis.Arf controls Mdm2, which in turn regulates p53, but Arf and Mdm2 also have p53-independent functions that affect tumor development.Moreover, inhibition of oncogene-induced tumorigenesis relies on Arf and p53, but the requirements of Arf and p53 in tumor
The acquisition of new motor skills is essential throughout daily life and involves the processes of learning new motor sequence and encoding elementary aspects of new movement.Although previous animal studies have suggested a functional importance for striatal dopamine release in the learning of new motor sequence, its role in encoding elementary
The article defines the importance of patriotic education of the modern generation of youth.The need for the formation of patriotism among students studying in the defense specialties of universities, which is distinguished by an orientation towards the specifics of future professional Xpel Diuretic activity, defined as professionally oriented patr
Management of technology is crucial for all of us.It involves dealing with technical issues across a broad spectrum of functional areas.Recent innovations in the form of total quality management, reengineering work process, flexible manufacturing system have one thing in common serving the customer well thought improved operational efficiency.For i